Following a 6-week dietary intervention in which the children followed a strict written nutritional plan approved by a dietician, weight, BMI, and BMI z-score were all significantly reduced from 58.6 kg to 56.8 kg, 25.7 kg/m2 to 24.2 kg/m2, and 2.2 to 2.0, respectively. These changes were accompanied by a significant decrease in the maximum exercise-induced fall in FEV1, at 21.8% compared with 30.6% at baseline, as well as a reduced FEV1 recovery time. And, in the 17 children who lost weight during the intervention, the reduction in BMI z-score correlated significantly with the fall in FEV1. Additionally, median scores on the Pediatric Asthma Quality of Life Questionnaire significantly improved, from 6.2 to 6.5 after the diet a clinically relevant change as did those for the individual domains of symptoms (5.9 vs 6.6) and activity limitations (5.8 vs 6.2). This improvement could be due to both weight loss and reduction in the severity of EIB, as excessive body weight is associated with an additional decrease in quality of life in children with asthma, comment van Leeuwen and colleagues.
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The low rate of major complications is significant given that the teens were severely obese and had significant obesity-related health issues, said study author Dr. Thomas Inge, of the Cincinnati Children’s Hospital Medical Center, and colleagues. Inge’s team said further research is needed to assess long-term outcomes for teens who have weight-loss surgery. More information The U.S.
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